sparks wrote:Live forever?
I doubt a pill can do that anyway.
Here's a couple of non-Daily Mail links:
http://news.harvard.edu/gazette/story/2 ... lar-aging/
https://arstechnica.com/science/2017/03 ... na-damage/
Approximately ten thousand times each day, the DNA in our cells receives some damage, but most of that damage is repaired by our cells' built-in DNA repair systems. The efficiency of these DNA repair systems decline with age, however, and that's thought to lead to age-related health problems and cancer.
A recent paper published in Science shows that a chemical used in the DNA repair process, nicotinamide adenine dinucleotide (NAD+), has a concentration that declines with age. This decline may drive the age-associated accumulation of DNA damage—a finding that suggests supplementing NAD+ might offset some of the effects of aging.
To test this proposed mechanism in a living organism, the authors used aging mice. As expected, NAD+ concentrations declined as the mice aged. With its decline, DBC1 was increasingly binding to and shutting down the DNA repair enzyme. The authors then gave the mice the chemical precursor to NAD+, which should restore their NAD+ concentrations. Once the mice were given this treatment, their DNA repair activity increased, and the levels of DNA damage were reduced.
It's important to note that this is in comparison with untreated, aged mice. The effect was not quantified relative to the DNA repair in young mice, so we don't know how much of a restoration this is.
This paper does not definitively explain all age-related increases in DNA damage—there may be other mechanisms at play. But it does suggest there's an NAD+ dependent mechanism that may contribute to this phenomenon. Based on this finding, the authors suggest that replenishing NAD+ concentrations could alleviate the effects of certain DNA-damaging exposures, such as chemotherapy and radiation.
All very interesting, but considerably less "too good to be true" than a pill that can reverse aging or allow you to live forever.
Of course, even if such a pill did exist, you could always just stop taking it, or end your life by other means.
A fool thinks himself to be wise, but a wise man knows himself to be a fool.